郑鹏生
研究领域（方向）
生殖内分泌疾病的临床及基础研究； 宫颈癌干细胞及微环境研究
个人及工作简历
1980.09-1985.08 中国、西安医科大学 学士（临床医学）
1985.09-1988.08 中国、白求恩医科大学 硕士（内科血液病学）
1990.09-1993.08 中国、白求恩医科大学 博士（妇产科学）
1994.04-1997.09 日本、佐贺医科大学 博士（妇产科学/妇科肿瘤）
1997.10-1998.11 加拿大纽芬兰纪念大学 博士后（宫颈癌分子病毒学）
1998.12-2000.11 美国国立卫生研究院（NIH） 博士后（宫颈癌分子病毒学）
2000.12-2005.10 加拿大多伦多大学 研究助理（肿瘤微环境研究）
2005.11-至今 中国西安交大医学院 教授/研究员（宫颈癌干细胞研究）
2007.07-至今 中国西安交大一附院 教授/主任（生殖医学临床与研究）
科研项目
2014获国家基金委面上项目- Wnt信号通路在宫颈癌干细胞自我更新中的作用机制研究（No: 81472728） 2012获国家基金委面上项目-习惯性流产补体激活研究（No: 81270751)
2010获国家教育部985-3期项目-癌干细胞与微环境研究
2007获国家基金委杰出青年科学基金项目-宫颈癌干细胞与微环境研究（No:30725043）
2006获国家教育部985-2期项目-癌干细胞研究
2005获国家基金委面上项目-宫颈癌干细胞研究（No:30571951）
学术及科研成果、专利、论文
2005年回国后发表的英文学术论著（*责任作者）
1. Wang HY, Lian P, Peng-Sheng Zheng*. SOX9, a potential tumor suppressor in cervical cancer, transactivates p21WAF1/CIP1 and suppresses cervical tumor growth. Oncotarget. 2015 May 16. [Epub ahead of print] [SCI 6.627]
2. Wu Y1, Gu TT2, Peng-Sheng Zheng*. CIP2A cooperates with H-Ras to promote epithelial-mesenchymal transition in cervical-cancer progression. Cancer Letters. 2015 356:646-655. [SCI 5.127]
3. Zhao K1, Jin M2, Chen Q1, Peng-Sheng Zheng*. Polysaccharides produced by Enterobacter cloacae induce apoptosis in cervical cancer cells. Int J Biol Macromol. 2015 72:960-964. [SCI 3.127]
4. Wang HY1, Peng-Sheng Zheng*. A Comparison of the Efficacy of Two Doses of Letrozole Alone or with Continuous Recombinant Follicle-Stimulating Hormone for Ovulation Induction in Anovulatory Women. Gynecol Obstet Invest. Gynecol Obstet Invest. 2015 79(4):250-5. [SCI 2.523]
5. Xian Liu, Wen-Ting Yang and Peng-Sheng Zheng*. Msi1 Promotes Tumor Growth and Cell Proliferation by Targeting Cell Cycle Checkpoints Proteins p21, p27 and p53 in Cervical Carcinomas. Oncotarget 2014, 5(21):10870-85. [SCI 6.627]
6. Qing Chen, Hao-Zhe Cao and Peng-Sheng Zheng*. LGR5 Promotes the Proliferation and Tumor Formation of Cervical Cancer Cells through Wnt/β-catenin Signaling Pathway. Oncotarget 2014, 5(19): 9092-105 [SCI 6.627]
7. Qing Chen, Xin Zhang, WM Li, YQ Ji, HZ Chao and Peng-Sheng Zheng*. Grape Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis. PLOS One 2014 9(9): e107013 [SCI 3.534].
8. Qing Chen, Xiao-Fang Liu and Peng-Sheng Zheng*. Grape seed proanthocyanidins (GSPs) inhibit the growth of cervical cancer by inducing apoptosis mediated by the mitochondrial pathway. PLOS One 2014 9(9): e107045 [SCI 3.534].
9. Li B, Xiao L, Wang ZY, Peng-Sheng Zheng*. Knockdown of STIM1 inhibits 6-hydroxydopamine-induced oxidative stress through attenuating calcium-dependent ER stress and mitochondrial dysfunction in undifferentiated PC12 cells. Free Radic Res. 2014 Jul 48(7):758-68[SCI 2.989].
10. Yang WT and Peng-Sheng Zheng*. The Promoter Hypermethylation of KLF4 Inactivates Its Tumor Suppressor Function in Cervical Carcinogenesis. PLOS One 2014 9(2): e88827 [SCI 3.534].
11. Xiao-Fang Liu, Wen-Ting Yang, Rui Xu, Jun-Tian Liu and Peng-Sheng Zheng*. Cervical Cancer Cells with Positive SOX2 Expression Share the Properties of Cancer Stem Cells. PLOS One 2014, 9(1):e87092 [SCI 3.534].
12. Shu-Yan Liu and Peng-Sheng Zheng*. High Aldehyde Dehydrogenase Activity Identifies Cancer Stem Cells in Human Cervical Cancer. Oncotarget 2013,4(12):2462-2475 [SCI 6.636]
13. Yi-Dong Wang, Na Cai, Xiao-Ling Wu, Hao-Zhe Cao, Li-Li Xie and Peng-Sheng Zheng*. OCT4 promotes carcinogenesis and inhibits apoptosis in cervical cancer via miR-125b/bak1 pathway. Cell Death and Disease. 2013 Aug 8 4:e760.[SCI 6.031].
14. Xiao-Ling Wu and Peng-Sheng Zheng*. Undifferentiated Embryonic Cell Transcription Factor-1 (UTF1) Inhibits the Growth of Cervical Cancer Cells by Transactivating p27Kip1 Carcinogenesis 2013 34：1660-1668 [SCI 5.635].
15. Cai N, Peng-Sheng Zheng*. MicRNA-302 inhibited the growth of cervical cancer cells through Akt pathway. RNA. 2013 19：85-95 [SCI 5.088]
16. Rui Xu, Wen-Ting Yang, and Peng-Sheng Zheng*. Coexpression of B-lymphoma Moloney murine leukemia virus insertion region-1 and sex-determining region of Y chromosome–related high mobility group box-2 in cervical carcinogenesis. Hum Pathol. 2013 44: 208-217 [SCI 2.876].
17. Wen-Ting Yang, Peng-Sheng Zheng *. Krüppel-like factor 4 functions as a tumor suppressor in cervical carcinoma. Cancer 2012, 118(15) 3691-3702. [SCI 5.201]
18. Ting-Ting Gu, Shu-Yan Liu, and Peng-Sheng Zheng*. Cytoplasmic NANOG-Positive Stromal Cells Promote Human Cervical Cancer Progression. The American Journal of Pathology. 2012, 181(2) 652-661. [SCI 4.552]
19. Yi Wu, Xi Zhou, Peng-Sheng Zheng*. Involvement of CD147 isoform 4 in the proliferation of SiHa cells: A possible molecular mechanism of cervical cancer. Oncology Reports. 2011, 26(3): 717-724. [SCI 1.686].
20. Ji J, Peng-Sheng Zheng*. Expression of Sox2 in human cervical carcinogenesis. Hum Pathol. 2010 , 41(10) 1438-1447 . [SCI 2.998]
21. Zhang Y, Li B, Ji ZZ, Peng-Sheng Zheng*. Notch1 regulates the growth of human colon cancers. Cancer. 2010, 116:5207-18. [SCI 5.437]
22. Ji J and Peng-Sheng Zheng* Activation of mTOR signaling pathway contributes to survical of cervical cancer cells. Gynecol Oncol. 2010, 117(1):103-8. [SCI 3.760].
2005年回国前发表的英文学术论著
1．Bing L Yang, Joel Finkelstein, Peng-Sheng Zheng, Zhaoqiong Deng, and Burton Yang The effect of versican G3 domain on local breast cancer invasiveness and bony metastasis Breast Cancer Res. 2007 9(4): R47. Published online 2007 July 27. [SCI 4.371]
2． Peng-Sheng Zheng, Marciano Reis, Cathy Sparling, Daniel Y. Lee, David P. La Pierre, Chung-Kwun Amy Wong, Zhaoqun Deng, Shireen Kahai, Jianping Wen, and Burton B. Yang. Versican G3 Domain Promotes Blood Coagulation through Suppressing the Activity of Tissue Factor Pathway Inhibitor-1. Journal of Biological Chemistry 2006 281 (12):8175-82. [SCI 5.808]
3． Peng-Sheng Zheng, Jane Brokaw and Alison A. McBride. Conditional Mutations in the Mitotic Chromosome Binding Function of the BPV-1 E2 Proteins. Journal of Virology. 2005；79（3）：1500-1509. [SCI 5.398]
4． Sheng W, Wang G, Wang Y, Liang J, Wen J, Zheng PS, Wu Y, Lee V, Slingerland J, Dumont D, Yang BB. The Roles of Versican V1 and V2 Isoforms in Cell Proliferation and Apoptosis. Mol Biol Cell. 2005, 78: 456-463. [SCI 7.517]
5． Peng-Sheng Zheng, Marciano Reis, Cathy Sparling, Daniel Y. Lee, David P. La Pierre, Chung-Kwun Amy Wong, Zhaoqun Deng, Shireen Kahai, Jianping Wen, and Burton B. Yang. Versican G3 Domain Promotes Blood Coagulation through Suppressing the Activity of Tissue Factor Pathway Inhibitor-1. Journal of Biological Chemistry 2006 281 (12):8175-82. [SCI 5.808]
6． Peng-Sheng Zheng, Jane Brokaw and Alison A. McBride. Conditional Mutations in the Mitotic Chromosome Binding Function of the BPV-1 E2 Proteins. Journal of Virology. 2005；79（3）：1500-1509. [SCI 5.398]
7． Sheng W, Wang G, Wang Y, Liang J, Wen J, Zheng PS, Wu Y, Lee V, Slingerland J, Dumont D, Yang BB. The Roles of Versican V1 and V2 Isoforms in Cell Proliferation and Apoptosis. Mol Biol Cell. 2005, 78: 456-463. [SCI 7.517]
8． Peng-Sheng Zheng, Vais D, Lapierre D, Liang YY, Lee V, Yang BL, Yang BB. P-Selectin Glycoprotein Ligand-1 (PSGL-1) Binds to PG-M/Versican and Mediates Leukocyte Aggregation. Journal of Cell Science 2004, 117: 5887-5895. [SCI 6.91]
9． Peng-Sheng Zheng, J. Wen, Lee Cyn Ang, W. Sheng, A. Viloria-Petit, Y. Wang, R. S. Kerbel and Burton B. Yang. Versican/PG-M G3 Protein Promotes Tumor Growth and Angiogenesis FASEB J. 2004 Apr 18(6): 754-756. Epub 2004 Feb 06. [SCI 6.82]
10． Kiani C, Chen L, Lee V, Zheng PS, Wu Y, Wen J, Cao L, Adam ME, Sheng W and Yang BB. Identification of the motifs and amino acids in aggrecan G1 and G2 domains involved in product secretion. Biochemistry 2003 42(23): 7226-7237. [SCI 4.278]
11． Wu Y, Chen L, Zheng PS, Yang BB. Beta1-integrin mediated Glioma Cell Adhesion and Free Radical-Induced Apoptosis Are Regulated by Binding to a C-terminal Domain of PG-M/Versican. J Biol Chem. 2002 277(25):22279-22288. [SCI 6.355]
12． Wu Y, Zhang Y, Cao L, Chen L, Lee V, Zheng PS, Kiani C, Adams ME, Ang LC, Paiwand F, Yang BB. Identification of the Motif in Versican G3 Domain That Plays a Dominant-negative Effect on Astrocytoma Cell Proliferation through Inhibiting Versican Secretion and Binding. J Biol Chem. 2001 276 (17):14178-14186. [SCI 7.368]
13． Peng-Sheng Zheng, Tsuyoshi Iwasaka, Alan Pater and Hajime Sugimori. Telomerase for cervical screening: complementing Papanicolaou smear and associating with oncogenic human papillomavirus. (English) Gynecologic Oncology 2000, 77:394-398. [SCI 2.5]
14． Tsuyoshi Iwasaka, Peng-Sheng Zheng, Masatoshi Yokoyama, Koichi Fukuda, Yoshifumi Nakao, Hajime Sugimori. Telomerase activity in cervical dysplasia. Obstetrics & Gynecology (English) 1998 91: 260-262. [SCI 2.091]
15． Peng-Sheng Zheng, Tsuyoshi Iwasaka, Masatoshi Yokoyama, Yoshifumi Nakao, Alan Pater, Hajime Sugimori. Telomerase activation in in vitro and in vivo cervical carcinogenesis Gynecologic Oncology (English) 1997 66, 222-226. [SCI 2.5]
16． Peng-Sheng Zheng, Tsuyoshi Iwasaka, Fumio Yamasaki, Mamoru Ouchida, Masatoshi Yokoyama, Yoshifumi Nakao, Koichi Fukuda, Toshitake Matsuyama and Hajime Sugimori. Telomerase activity in gynecologic tumors. Gynecologic Oncology (English) 1997 64, 171-175. [SCI 2.5]
17． Tsuyoshi Iwasaka, Peng-Sheng Zheng, Mamoru Ouchida, Fumio Yamasaki, Masatoshi Yokoyama and Hajime Sugimori. Cytologic changes in two cervical carcinoma cell lines after transfection of the wild-type p53 gene. Acta Obstetricia et Gynecologica Scandinavica(English) 1996 75, 797-803. [SCI 1.028]
18． Peng-Sheng Zheng, Tsuyoshi Iwasaka, Mamoru Ouchida, Koichi Fukuda, Masatoshi Yokoyama, Hajime Sugimori. Growth suppression of a cervical cancer cell line (TMCC-1) by human wild type p53 gene. Gynecologic Oncology (English). 1996 60, 245-250. [SCI 2.5]
19． Peng-Sheng Zheng, Shou-Rou Li, Tsuyoshi Iwasaka, Jie Song, Man-Hua Cui, Hajime Sugimori. Simultaneous detection by consensus multiplex PCR of high and low risk and other types of human papilloma virus in clinical samples. Gynecologic Oncology (English). 1995 58, 179-183. [SCI 2.5]
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